Preeti Gupta Lal PhD.
Dr. Preeti Gupta Lal is the Chief Scientific Officer (CSO) of Vgenomics. She has 30+ years of research experience in the field of data science, translational medicine, and clinical biomarker implementation across various phases of clinical trial development. Her innovative mindset and commitment to pushing the boundaries of medical science is reflected by her track record of co-inventing 150 plus patents.
Her professional journey spans across renowned healthcare companies, including Alladapt Immunotherapeutic, Roche Diagnostics, Gilead Sciences, Genentech, CareDx, and Incyte Genomics. At each organization, she has played instrumental roles in advancing translational medicine and data science initiatives, driving companion diagnostic programs, and contributing to biomarker development across various therapeutic indications. She has extensive experience in regulatory interactions with both the drug and device divisions of the FDA as well.
With a solid background in managing bioinformatics teams and collaborating with pharmaceutical partners, she brings a wealth of expertise to Vgenomics.
Research articles
Dr. Lal’s research focuses on transcriptional and translational biology.
Transcriptional signals of T-cell and corticosteroid-sensitive genes are associated with future acute cellular rejection in cardiac allografts
Background: Profiling mRNA levels of 11 informative genes expressed by circulating immune effector cells identifies cardiac allograft recipients at low risk for current moderate-severe acute cellular rejection (ACR). Methods: We conducted a nested case-control study of 104 cardiac allograft recipients to investigate the association of transcriptional profiles of blood samples with either a future rejection episode within 12 weeks of a baseline clinical sample or persistent histologic quiescence for the same time period…
Clinical implications and longitudinal alteration of peripheral blood transcriptional signals indicative of future cardiac allograft rejection
Background: We have previously demonstrated that a peripheral blood transcriptional profile using 11 distinct genes predicts onset of cardiac allograft rejection weeks to months prior to the actual event. Methods: In this analysis, we ascertained the performance of this transcriptional algorithm in a Bayesian representative population: 28 cardiac transplant recipients who progressed to moderate to severe rejection; 53 who progressed to mild rejection; and 46 who remained rejection-free. Furthermore, we characterized longitudinal…
Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling
Rejection diagnosis by endomyocardial biopsy (EMB) is invasive, expensive and variable. We investigated gene expression profiling of peripheral blood mononuclear cells (PBMC) to discriminate ISHLT grade 0 rejection (quiescence) from moderate/severe rejection (ISHLT > or = 3A). Patients were followed prospectively with blood sampling at post-transplant visits. Biopsies were graded by ISHLT criteria locally and by three independent pathologists blinded to clinical data…
Astrocyte-astrocytoma cell line interactions in culture
Astrocytomas are the most common brain tumors arising in the CNS and account for 65% of all primary brain tumors. Astrocytes have been shown to have the highest predisposition to malignant transformation compared to any other CNS cell type. The majority of astrocytomas are histologically malignant neoplasm. Previous studies have shown that resident astrocytes are the first cell type to react to tumors and surround them…
Astrocytoma and Schwann cells in coculture
Glial fibrillary acidic protein (GFAP) is the principal intermediate filament protein found in mature astrocytes. Although the exact function of GFAP is poorly understood, it is presumed to stabilize the astrocyte’s cytoskeleton and help in maintaining cell shape. Previous studies from our laboratory have shown that when astrocytes were cocultured with primary Schwann cells (pSCs), astrocytes became hypertrophied and fibrous with intensely positive GFAP staining and segregated Schwann cells (SCs) into pockets…
Expression of glutamate uptake transporters after dibutyryl cyclic AMP differentiation and traumatic injury in cultured astrocytes
Our findings indicate that differentiation of primary astrocytes by dibutyryl cyclic adenosine monophosphate (dBcAMP) and scratch injury together resulted in increased glutamate transporter gene expression. Confluent primary cultures were prepared from cerebral cortex of normal new born rat pups. The primary cultures were then divided into four groups each: control and scratch-injured, and dBcAMP-treated control and scratch-injured cultures…
Patents
Preeti Gupta Lal is a co-inventor of 150+ patents.
| PATENT ID | PATENT NAME | PATENT LINK |
|---|---|---|
| US-9914921-B2 | Secreted proteins | |
| US-8716445-B2 | Compositions comprising signal peptide-containing proteins | |
| US-8148067-B2 | Methods for diagnosing and monitoring the status of systemic lupus erythematosus | |
| US-8206947-B2 | Human transmembrane proteins | |
| US-7645575-B2 | Genes useful for diagnosing and monitoring inflammation related disorders | |
| US-2008241158-A1 | Human taste-specific receptor TIR3 | |
| WO-2010075249-A3 | A method for treating rheumatoid arthritis with b-cell antagonists | |
| US-2014227278-A1 | Antibodies to human signal peptide-containing proteins | |
| US-2016282350-A1 | Methods of diagnosing cancer | |
| WO-2004027022-A2 | Enzymes | |
| WO-2004067712-A3 | Intracellular signaling molecules | |
| AU-2003279799-A1 | Proteins associated with cell growth, differentiation, and death | |
| WO-02094990-A3 | Receptors and membrane-associated proteins | |
| CA-2445366-A1 | Molecules for disease detection and treatment | |
| AU-2002365195-A1 | Intracellular signaling molecules | |
| AU-2003294510-A8 | Transporters and ion channels | |
| WO-2004035755-A2 | Transporters and ion channels | |
| EP-1390396-A2 | Molecules for disease detection and treatment | |
| CA-2420105-A1 | Human kinases | |
| CA-2406399-A1 | Human kinases | |
| CA-2413186-A1 | Extracellular matrix and cell adhesion molecules | |
| WO-03008625-A2 | Structural and cytoskeleton-associated proteins | |
| AU-2002251911-A1 | Receptors and membrane-associated proteins | |
| AU-2002303843-A1 | Secreted proteins | |
| WO-0242330-A3 | Cystoskeleton-associated proteins | |
| EP-1379628-A2 | Kinases and phosphatases sequences, and use thereof | https://patents.google.com/patent/EP1379628A2/en |
| AU-2002303878-A1 | Kinases and phosphatases | https://patents.google.com/patent/AU2002303878A1/en |
| EP-1578899-A2 | Secreted proteins | https://patents.google.com/patent/EP1578899A2/en |
| AU-2002364926-A8 | Nucleic acid-associated proteins | https://patents.google.com/patent/AU2002364926A8/en |
| AU-2002227352-A1 | Human kinases | https://patents.google.com/patent/AU2002227352A1/en |
| CA-2437571-A1 | Receptors and membrane-associated proteins | https://patents.google.com/patent/CA2437571A1/en |
| AU-2002347778-A1 | Enzymes | https://patents.google.com/patent/AU2002347778A1/en |
| AU-2002362935-A1 | Kinases and phosphatases | https://patents.google.com/patent/AU2002362935A1/en |
| AU-2003211112-A1 | Secreted proteins | https://patents.google.com/patent/AU2003211112A1/en |
| WO-02090530-A3 | Kinases and phosphatases | https://patents.google.com/patent/WO2002090530A3/en |
| AU-2002364890-A8 | Molecules for disease detection and treatment | https://patents.google.com/patent/AU2002364890A8/en |
| WO-03039348-A2 | Intracellular signaling molecules | https://patents.google.com/patent/WO2003039348A2/en |
| WO-03087300-A2 | Secreted proteins | https://patents.google.com/patent/WO2003087300A2/en |
| US-7029897-B2 | Human protein phosphatase 2C | https://patents.google.com/patent/US7029897B2/en |
| US-6927056-B2 | Proteases | https://patents.google.com/patent/US6927056B2/en |
| AU-2002247042-A1 | Secreted proteins | https://patents.google.com/patent/AU2002247042A1/en |
| AU-2002257273-A1 | Enzymes | https://patents.google.com/patent/AU2002257273A1/en |
| AU-2002258657-A1 | Secreted proteins | https://patents.google.com/patent/AU2002258657A1/en |
| AU-2003231981-A8 | Protein modification and maintenance molecules | https://patents.google.com/patent/AU2003231981A8/en |
| WO-03006618-A2 | Nucleic acid-associated proteins | https://patents.google.com/patent/WO2003006618A2/en |
| CA-2410084-A1 | Transporters and ion channels | https://patents.google.com/patent/CA2410084A1/en |
| AU-2002345422-A1 | Nucleic acid-associated proteins | https://patents.google.com/patent/AU2002345422A1/en |
| AU-2002227279-A1 | Polynucleotide and polypeptide sequences of putative transporters and ion channells | https://patents.google.com/patent/AU2002227279A1/en |
| AU-2002254466-A1 | G-protein coupled receptors | https://patents.google.com/patent/AU2002254466A1/en |
| CA-2414387-A1 | Drug metabolizing enzymes | https://patents.google.com/patent/CA2414387A1/en |
| WO-02059312-A3 | Cell adhesion proteins | https://patents.google.com/patent/WO2002059312A3/en |
| AU-2002258724-A1 | Protein modification and maintenance molecules | https://patents.google.com/patent/AU2002258724A1/en |
| CA-2447647-A1 | Lipid-associated molecules | https://patents.google.com/patent/CA2447647A1/en |
| WO-02053719-A3 | Cytoskeleton-associated proteins | https://patents.google.com/patent/WO2002053719A3/en |
| WO-03046151-A3 | Nucleic acid-associated proteins | https://patents.google.com/patent/WO2003046151A3/en |
| EP-1427841-A2 | Nucleic acid-associated proteins | https://patents.google.com/patent/EP1427841A2/en |
| AU-2002239543-A1 | Molecules for disease detection and treatment | https://patents.google.com/patent/AU2002239543A1/en |
| WO-02090521-A2 | Drug metabolizing enzymes | https://patents.google.com/patent/WO2002090521A2/en |
| CA-2422497-A1 | Transporters and ion channels | https://patents.google.com/patent/CA2422497A1/en |
| WO-02062841-A3 | Secreted proteins | https://patents.google.com/patent/WO2002062841A3/en |
| WO-02078420-A3 | Molecules for disease detection and treatment | https://patents.google.com/patent/WO2002078420A3/en |
| WO-0229036-A3 | Lipid metabolism enzymes | https://patents.google.com/patent/WO2002029036A3/en |
| WO-0231151-A3 | Lipocalins | https://patents.google.com/patent/WO2002031151A3/en |
| EP-1497319-A2 | Cell adhesion and extracellular matrix proteins | https://patents.google.com/patent/EP1497319A2/en |
| EP-1423511-A2 | Nucleic-acid associated proteins | https://patents.google.com/patent/EP1423511A2/en |
| EP-1390391-A4 | Transporters and ion channels | https://patents.google.com/patent/EP1390391A4/en |
| AU-2002306448-A1 | Transporters and ion channels | https://patents.google.com/patent/AU2002306448A1/en |
| AU-2002332573-A8 | Transporters and ion channels | https://patents.google.com/patent/AU2002332573A8/en |
| AU-2002238070-A1 | Molecules for disease detection and treatment | https://patents.google.com/patent/AU2002238070A1/en |
| WO-2004013293-A2 | Transporters and ion channels | https://patents.google.com/patent/WO2004013293A2/en |
| AU-2003239871-A8 | Protein modification and maintenance molecules | https://patents.google.com/patent/AU2003239871A8/en |
| AU-2002248210-A1 | Cell adhesion proteins | https://patents.google.com/patent/AU2002248210A1/en |
| AU-2002303865-A1 | Transporters and ion channels | https://patents.google.com/patent/AU2002303865A1/en |
| AU-2002243466-A1 | Cytoskeleton-associated proteins | https://patents.google.com/patent/AU2002243466A1/en |
| AU-2002236984-A1 | Proteins associated with cell growth, differentiation, and death | https://patents.google.com/patent/AU2002236984A1/en |
| WO-02064795-A3 | Putative human enzymes | https://patents.google.com/patent/WO2002064795A3/en |
| AU-2002239570-A1 | Polypeptide sequences of drug metabolizing enzymes and polynucleotide sequences coding therefor | https://patents.google.com/patent/AU2002239570A1/en |
| EP-1358330-A2 | Transporters and ion channels | https://patents.google.com/patent/EP1358330A2/en |
| WO-0250279-A2 | Nucleic acid-associated proteins | https://patents.google.com/patent/WO2002050279A2/en |
| WO-02097032-A2 | Proteins associated with cell growth, differentiation, and death | https://patents.google.com/patent/WO2002097032A2/en |
| EP-1434796-A2 | Secreted proteins | https://patents.google.com/patent/EP1434796A2/en |
| CA-2436732-A1 | Protein modification and maintenance molecules | https://patents.google.com/patent/CA2436732A1/en |
| EP-1385977-A2 | Secreted proteins | https://patents.google.com/patent/EP1385977A2/en |
| CA-2427085-A1 | Transmembrane proteins | https://patents.google.com/patent/CA2427085A1/en |
| CA-2443897-A1 | Transporters and ion channels | https://patents.google.com/patent/CA2443897A1/en |
| WO-03004615-A3 | Secreted proteins | https://patents.google.com/patent/WO2003004615A3/en |
| CA-2434953-A1 | Protein modification and maintenance molecules | https://patents.google.com/patent/CA2434953A1/en |
| WO-03031568-A2 | Intracellular signaling molecules | https://patents.google.com/patent/WO2003031568A2/en |
| CA-2453985-A1 | Receptors and membrane-associated proteins | https://patents.google.com/patent/CA2453985A1/en |
| EP-1387886-A2 | Proteases | https://patents.google.com/patent/EP1387886A2/en |
| EP-1412387-A2 | Transporters and ion channels | https://patents.google.com/patent/EP1412387A2/en |
| WO-0238602-A2 | Secreted proteins | https://patents.google.com/patent/WO2002038602A2/en |
| EP-1409535-A2 | Human secreted proteins | https://patents.google.com/patent/EP1409535A2/en |
| AU-2001291011-A1 | Transporters and ion channels | https://patents.google.com/patent/AU2001291011A1/en |
| WO-02070709-A2 | Molecules for disease detection and treatment | https://patents.google.com/patent/WO2002070709A2/en |
| AU-2001294866-A1 | Transferases | https://patents.google.com/patent/AU2001294866A1/en |
| WO-03077875-A3 | Proteins associated with growth, differentiation, and death | https://patents.google.com/patent/WO2003077875A3/en |
| AU-2002352912-A1 | Secreted proteins | https://patents.google.com/patent/AU2002352912A1/en |
| AU-2003295824-A1 | Cell adhesion and extracellular matrix proteins | https://patents.google.com/patent/AU2003295824A1/en |
| EP-1436383-A2 | Secreted proteins | https://patents.google.com/patent/EP1436383A2/en |
| EP-1444254-A2 | Molecules for disease detection and treatment | https://patents.google.com/patent/EP1444254A2/en |
| AU-2002364699-A1 | Receptors and membrane-associated proteins | https://patents.google.com/patent/AU2002364699A1/en |
| WO-03016506-A2 | Secreted proteins | https://patents.google.com/patent/WO2003016506A2/en |
| WO-03025130-A2 | Receptors and membrane-associated proteins | https://patents.google.com/patent/WO2003025130A2/en |
| WO-2004009778-A3 | Kinases and phosphatases | https://patents.google.com/patent/WO2004009778A3/en |
| WO-0236757-A3 | Enzymes involved in glycoprotein and glycolipid metabolism | https://patents.google.com/patent/WO2002036757A3/en |
| AU-2002327419-A1 | Kinases and phosphatases | https://patents.google.com/patent/AU2002327419A1/en |
| AU-2002359333-A1 | Nucleic acid-associated proteins | https://patents.google.com/patent/AU2002359333A1/en |
| EP-1451212-A2 | Structural and cytoskeleton-associated proteins | https://patents.google.com/patent/EP1451212A2/en |
| AU-2001297737-A1 | Nucleic acid-associated proteins | https://patents.google.com/patent/AU2001297737A1/en |
| CA-2448148-A1 | Carbohydrate-associated proteins | https://patents.google.com/patent/CA2448148A1/en |
| AU-2003268023-A1 | Protein modification and maintenance molecules | https://patents.google.com/patent/AU2003268023A1/en |
| WO-02072861-A1 | Cd53 cell surface antigen | https://patents.google.com/patent/WO2002072861A1/en |
| US-6692923-B2 | Tapasin-like protein | https://patents.google.com/patent/US6692923B2/en |
| AU-2003205353-A1 | Protein modification and maintenance molecules | https://patents.google.com/patent/AU2003205353A1/en |
| AU-2002351194-A1 | Cell adhesion and extracellular matrix proteins | https://patents.google.com/patent/AU2002351194A1/en |
| WO-2004100774-A3 | Receptors and membrane-associated proteins | https://patents.google.com/patent/WO2004100774A3/en |
| WO-02079404-A2 | Cytoskeleton-associated proteins | https://patents.google.com/patent/WO2002079404A2/en |
| AU-2003295437-A1 | Receptors and membrane-associated proteins | https://patents.google.com/patent/AU2003295437A1/en |
| WO-0240658-A3 | Isomerases | https://patents.google.com/patent/WO2002040658A3/en |
| WO-02077231-A3 | Nucleic acid-associated proteins | https://patents.google.com/patent/WO2002077231A3/en |
| WO-02059283-A2 | Nucleic acid modification enzymes | https://patents.google.com/patent/WO2002059283A2/en |
| WO-02072596-A1 | Steap-related protein | https://patents.google.com/patent/WO2002072596A1/en |
| CA-2453833-A1 | Tnf receptor 2 related protein variant | https://patents.google.com/patent/CA2453833A1/en |
| WO-02061059-A3 | Carbohydrate metabolism enzymes | https://patents.google.com/patent/WO2002061059A3/en |
| US-6962799-B2 | Microtubule-associated proteins and tubulins | https://patents.google.com/patent/US6962799B2/en |
| WO-02068621-A3 | Rax-related protein | https://patents.google.com/patent/WO2002068621A3/en |
| AU-2002358273-A8 | Nucleic acid-associated proteins | https://patents.google.com/patent/AU2002358273A8/en |
| AU-2002334631-A1 | Immune response associated proteins | https://patents.google.com/patent/AU2002334631A1/en |
| AU-2002357147-A1 | Transporters and ion channels | https://patents.google.com/patent/AU2002357147A1/en |
| AU-2002252239-A1 | Steap-related protein | https://patents.google.com/patent/AU2002252239A1/en |
| AU-2002255677-A1 | Cd53 cell surface antigen | https://patents.google.com/patent/AU2002255677A1/en |
| WO-03056027-A1 | Carbohydrate-associated proteins | https://patents.google.com/patent/WO2003056027A1/en |
| WO-02079389-A3 | Nucleic acid-associated proteins | https://patents.google.com/patent/WO2002079389A3/en |
| AU-2002320089-A1 | Proteins associated with cell growth, differentiation, and death | https://patents.google.com/patent/AU2002320089A1/en |
| AU-2002258520-A1 | Nucleic acid-associated proteins | https://patents.google.com/patent/AU2002258520A1/en |
| WO-02066646-A3 | Neurotransmission-associated proteins | https://patents.google.com/patent/WO2002066646A3/en |
| AU-2002250095-A1 | Neurotransmission-associated proteins | https://patents.google.com/patent/AU2002250095A1/en |
| WO-03094848-A2 | Nucleic acid-associated proteins | https://patents.google.com/patent/WO2003094848A2/en |
| AU-2002246779-A1 | Carbohydrate metabolism enzymes | https://patents.google.com/patent/AU2002246779A1/en |
